Prof Sean Gaine is Consultant Respiratory Physician at Mater Misericordiae University Hospital in Dublin and director of the National Pulmonary Hypertension Unit. Prof Gaine completed his medical education at Trinity College Dublin and his medical residency and fellowship training at the Johns Hopkins Hospital, Baltimore. During his Pulmonary and Critical Care fellowship Prof Gaine obtained his PhD for work exploring the control of pulmonary vasculature function. He subsequently held faculty positions at the Johns Hopkins Hospital and at the University Of Maryland School Of Medicine. He established the Pulmonary Hypertension Center at the Johns Hopkins Hospital in 1999 and subsequently the National Pulmonary Hypertension Unit upon his return to Dublin. His research interests include novel biomarkers and new therapeutic agents in pulmonary vascular diseases. Prof Gaine has been a working member of the European Society of Cardiology and European Respiratory Society guidelines committee on Pulmonary Hypertension in the past and a task force member of the WHO World PH symposiums since 2003. Professor Gaine is a member of numerous international associations, and is a Fellow of the College of Chest Physicians, the Royal College of Physicians in Ireland and the Faculty of Sports and Exercise Medicine. He is Chief Medical Officer of the Olympic Council of Ireland and led the medical team at the Olympic Games in Athens, Beijing and London.